Pathological study of higher brain dysfunction as a neurological outcome in extremely preterm infants

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Recently, higher brain dysfunction including hyperactivity and learning disability have been highlighted as neurological outcome of the extremely preterm infants. We hypothesized that the brain ischemia in the extremely preterm infants may result in injuries to the neurons migrating to cortex, subsequently damaging the developing cerebral cortex and causing higher brain dysfunction. In this study, we sought to establish a mouse model for prenatal ischemic brain injuries and delineated the cellular pathological basis for the higher brain dysfunction in extremely preterm infants.