Effective systems delivering drugs to the skin using nanoneedle
Effective systems delivering drugs to the skin using nanoneedle
批准号:
21591452
负责人:
HANADA Katsumi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Development of the delivery systems which can introduce therapeutic molecules into targeting organs surely make a progress of treatments in clinical practice. We pay strong attention to a nanoneedle method. The needles containing drugs go into the skin, are broken, are remained and release the drugs to the skin. In this study, we first examined the appropriate length of the needle and then checked material properties of the needle. Next, we tried to introduce some dye into skin using the nanoneedles and we found the dye in the skin. However, introducing rate was not enough for protein and genes in the aspect of clinical use and we need to improve the introducing rate. In conclusion, this method is suggested to be potential for delivering the molecules into the skin.
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天疱疮研究组。
DOI:
--
发表时间:
2009
期刊:
J Am Acad Dermatol
影响因子:
13.8
作者:
[Amagai M, Ikeda S, Shimizu H, Iizuka H, Hanada K, Aiba S, Kaneko F, Izaki S, Tamaki K, Ikezawa Z, Takigawa M, Seishima M, Tanaka T, Miyachi Y, Katayama I, Horiguchi Y, Miyagawa S, Furukawa F, Iwatsuki K, Hide M, Tokura Y, Furue M, Hashimoto T, Ihn H, Fuji]
通讯作者:
Fuji
DOI:
10.1016/j.jaad.2008.09.052
发表时间:
2009-04-01
期刊:
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
影响因子:
13.8
作者:
[Amagai, Masayuki, Ikeda, Shigaku, Hashimoto, Koji]
通讯作者:
Hashimoto, Koji
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DOI:
--
发表时间:
2010
期刊:
影响因子:
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--
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DOI:
--
发表时间:
2009
期刊:
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作者:
[Morita S, Shirakata Y, et. al., 武藤正彦, 高橋健造, 武藤正彦]
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