Kicking and biting behavioral responses toward mechanical touch stimuli in stress-disorder model mouse

易激惹是精神疾病和/或发育障碍患者中广泛发生的DSM-IV症状。易激惹的行为症状也发生在实验室精神病模型动物中，例如应激和/或抑郁障碍。然而，在使用实验室动物的研究中尚未报道用于估计易怒的行为范例。精神药物评价研究需要建立精神病动物模型的应激性评估方案。在本研究中，我们开发了一种新的研究仪器，可以检测和记录的强度和发生率的触摸逃避行为和攻击行为对无生命的机械刺激。本研究以触觉逃避行为和攻击行为为范式，评估慢性应激小鼠的应激性，并评价精神药物对应激性的影响。本研究表明，这两种反应可以作为行为范式的定量分析的易怒。这两种范式似乎是有用的精神药物的药物评价使用相同的人反复。

Irritability is a widely occurring DSM-IV symptom in patients with psychiatric disorders and/or developmental disorders. Behavioral symptoms of irritability also occur in laboratory psychiatric model animals such as stress and/or depression disorders. However, behavioral paradigms for estimation of irritability have not been reported in studies using laboratory animals. Establishment of protocols for estimation of irritability in psychiatric animal models is needed to study psychotropic drug evaluations. In the present study, we developed a new research apparatus that can detect and record intensities and incidence rates of touch escape behavior and aggressive behavior toward inanimate mechanical stimuli. We estimated irritability in chronically stressed mice and evaluated the effects of psychotropic drugs on irritability using the touch escape behavior and aggressive behaviors as paradigms. The present study suggests that both responses can be used as behavioral paradigms in quantitative analyses of irritability. Both paradigms appear to be useful for drug evaluation of psychotropic agents using the same individuals repeatedly.