Developing screening method of autism using fractal analysis

利用分形分析开发自闭症筛查方法

• 批准号: 21591507
• 负责人: KITAMURA Hideaki
• 金额: $ 1万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591507/
• 关键词: 自閉症; アスペルガー障害; MRI; 脳; フラクタル解析

The aim of the present study was to apply fractal analysis of the human brain morphology to efficient screening of the autistic brains. Individuals with pervasive developmental disorders(PDD) and controls with typical development were recruited from clinic and community samples. Original MR images were then converted to BMP axial images and analyzed with Benoit for MatlabR specialized for fractal analysis of the imaging data. Three-dimensional fractal dimension(FD) was calculated as an index for estimating the complexity of the cortical folding and/or cortical volume. As predicted, two diagnostic groups were different both in cerebral and cerebellar FD. Compared to the controls, the PDD had smaller cerebral FD and larger cerebellar FD, suggesting aberrant or compensatory neurodevelopment in PDD and possible clinical use of the fractal analysis in this field.

本研究的目的是将人脑形态学的分形分析应用于自闭症患者大脑的有效筛查。从诊所和社区样本中招募了患有广泛性发育障碍（PDD）的个体和具有典型发育的对照组。然后将原始MR图像转换为BMP轴向图像，并使用专门用于图像数据分形分析的Benoit for MatlabR进行分析。计算三维分形维数（FD）作为估计皮质折叠和/或皮质体积的复杂性的指标。如预测的那样，两个诊断组在大脑和小脑FD方面都不同。与对照组相比，PDD具有较小的大脑FD和较大的小脑FD，这表明PDD中的异常或代偿性神经发育以及分形分析在该领域的可能临床用途。

项目成果

自閉症スペクトラム障害における小脳虫部の大きさと脳代謝物濃度

自闭症谱系障碍中的小脑蚓部大小和脑代谢物浓度

• 发表时间: 2010
• 作者: 北村秀明;田村立;遠藤太郎;ら
• 通讯作者: ら

Decreased leftward bias of prefrontal activity in autism spectrum disorder revealed by functional near-infrared spectroscopy

• DOI: 10.1016/j.pscychresns.2011.12.008
• 发表时间: 2012-08
• 期刊: Psychiatry Research: Neuroimaging
• 作者: R. Tamura;H. Kitamura;T. Endo;Ryo Abe;T. Someya

A case of wrist fracture during modified electroconvulsive therapy.

改良电休克治疗期间手腕骨折一例。

• 发表时间: 2009
• 期刊: Psychiatry Clin Neurosci 63(6)
• 作者: Uebaba S;Kitamura H;Someya T
• 通讯作者: Someya T

5-HTTLPR polymorphism influences prefrontal neuralchemical metabolites in autism spectrum disorder.

5-HTTLPR 多态性影响自闭症谱系障碍的前额神经化学代谢物。

• 发表时间: 2010
• 期刊: Psychiatry Res Neuroimaging 183(2)
• 作者: Endo T;Kitamura H;Tamura R;Egawa J;Sugai T;Fukui N;Suzuki Y;Someya T
• 通讯作者: Someya T

Reduced thalamic volwoe observed across different subgroups of autism spectrum disorders

在自闭症谱系障碍的不同亚组中观察到丘脑体积减少

• 发表时间: 2010
• 期刊: Psychiatry Res Neuroimaging
• 作者: Tamura R;Kitamura H;Endo T;et al.
• 通讯作者: et al.