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The study of new radiation therapy combined with high concentration ascorbic acid as to achieve high tumor local control rate

The study of new radiation therapy combined with high concentration ascorbic acid as to achieve high tumor local control rate
新型放射疗法联合高浓度抗坏血酸实现高肿瘤局部控制率的研究
批准号:
21591603
负责人:
HOSOKAWA Yoichiro
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
This study was conducted to examine the utility of the combined use of ascorbic acid (AsA) and radiation in clinical applications. AsA induced cell death and the number of living cells significantly decreased after combined X-ray irradiation and AsA treatment in comparison with that after X-ray irradiation alone in four all cell lines (HL60, HT1080, SAS, A549). This result suggested that the combined X-ray and AsA treatment was effective against cancer cells and the clinical applications should be examined in the future.
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DOI: 10.1007/s10637-010-9544-x
发表时间: 2012-02-01
期刊: INVESTIGATIONAL NEW DRUGS
影响因子: 3.4
作者: [Chai, Hongbo, Hazawa, Masaharu, Kashiwakura, Ikuo]
通讯作者: Kashiwakura, Ikuo
A convolution/superposition method using primary and scatter dose kernels formed for energy bins of X-ray spectra reconstructed as a function of off-axis distance : comparison of calculated and measured 10-MV X-ray doses in thorax-like phantoms
一种使用初级和散射剂量核的卷积/叠加方法,该核是为X射线光谱的能量仓而形成的,重建为离轴距离的函数:计算和测量的胸腔模型中10-MV X射线剂量的比较
DOI: --
发表时间: 2011
期刊: Radiol Phys Technol
影响因子: 1.6
作者: [Koji Shinozaki, Yoichiro Hosokawa, Masakatsu Hazasa, Ikuo Kashiwakura, Kazuhiko Okumura, Tohru Kaku, Eiji Nakayama, Akira Isasaki, Shigenobu Kimura]
通讯作者: Shigenobu Kimura
DOI: 10.1007/s11604-009-0376-6
发表时间: 2010-01-01
期刊: JAPANESE JOURNAL OF RADIOLOGY
影响因子: 2.1
作者: [Ohba, Hisateru, Narumi, Masakazu, Aoki, Masahiko]
通讯作者: Aoki, Masahiko
Ascorbic Acid Enhances Radiation-induced Apoptosis in an HL60 Human Leukemia Cell Line
抗坏血酸增强 HL60 人白血病细胞系中辐射诱导的细胞凋亡
DOI: --
发表时间: 2011
期刊: J Radiat Res
影响因子: 2
作者: [Koji Shinozaki, Yoichiro Hosokawa, Masakatsu Hazasa, Ikuo Kashiwakura, Kazuhiko Okumura, Tohru Kaku, Eiji Nakayama]
通讯作者: Eiji Nakayama
15
    Expression of hypoxia-inducible factor-1alpha (HIF-lalpha) and correlation with radiation resistance in human oral squamous cell carcinoma cell lines.
    • 批准号:
      15592001
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2003
    • 负责人:
      HOSOKAWA Yoichiro
    • 依托单位:
    海外基金