Effects of Sivelestat Sodium Hydrate on the prevention of lethal radiation induced lung damage

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Twelve-week-old female C57BL/6J mice were used. Neutrophil elastase inhibitor(Sivelestat Sodium Hydrate) was administered just before irradaiation and 1 hr., 3 hrs., and 6 hrs. after delivering a dose of 20 Gy to the whole lung in a single fraction. Neutrophil elastase inhibitor prevented and reduced severe acute lung damage which sometimes jeopardize the patient's life and improved the survival rate. Histopathological study proved that it also reduced the lung fibrosis followed by the acute lung damage. Neutrophil elastase inhibitor has promising effects on the reduction of the lung injury caused by radiation therapy.