Clinico-pathological research for predictive factors of the treatment effects in radiation therapy combined with or without chemotherapy for lung cancer

肺癌放疗联合化疗疗效预测因素的临床病理学研究

• 批准号: 21591617
• 负责人: HAYAKAWA Kazushige
• 金额: $ 3万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591617/
• 关键词: 肺癌; 放射線療法; 定位放射線治療; 分子標的薬; EGFR; 化学放射線療法; シスプラチン; ビノレルビン; Gefitinib; EGFR遺伝子; EGFR-TKI; 放射線治療

In the patients with peripheral stage I non-small cell lung cancer treated with stereotactic body radiotherapy, the 5-year overall survival rate, cause-specific survival rate and local progression-free rate were 63%, 74% and 72%, respectively. But the patients with squamous cell carcinoma of the lung had a worse prognosis. The immunohistochemical study for EGFR mutation showed that the heterogeneity of gene mutation commonly developed in the various types of lung cancer. The 6B6 antibody staining was specific for EGFR mutation and considered to be useful for screening patients effective to EGFR TKI.

周围型I期非小细胞肺癌立体定向体部放疗的5年总生存率、病因特异性生存率和无局部进展率分别为63%、74%和72%。但肺鳞状细胞癌患者预后较差。对EGFR突变的免疫组织化学研究表明，基因突变的异质性普遍存在于各种类型的肺癌中。6B6抗体染色对EGFR突变具有特异性，可用于筛选EGFR TKI有效患者。

项目成果

少数転移・少数再発(oligometastases, oligo-recurrence)に対する放射線治療

寡转移和寡复发的放射治疗

• 发表时间: 2010
• 期刊: 日独医報
• 作者: 新部譲;ほか3名
• 通讯作者: ほか3名

The radiotnerapy with methotrexate, vinblastine, doxorubicin, and cisplatin treatment is an effective therapeutic option in patients with advanced or metastatic bladder cancer

甲氨蝶呤、长春花碱、阿霉素和顺铂的放射治疗是晚期或转移性膀胱癌患者的有效治疗选择

• 发表时间: 2011
• 期刊: J Radiat Res
• 影响因子: 2
• 作者: Ikeda M;Hayakawa K;et al
• 通讯作者: et al

A PHASE II TRIAL OF NEOADJUVANT PREOPERATIVE CHEMORADIOTHERAPY WITH S-1 PLUS IRINOTECAN AND RADIATION IN PATIENTS WITH LOCALLY ADVANCED RECTAL CANCER: CLINICAL FEASIBILITY AND RESPONSE RATE

• DOI: 10.1016/j.ijrobp.2009.11.007
• 发表时间: 2011-03-01
• 期刊: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
• 影响因子: 7
• 作者: Sato, Takeo;Ozawa, Heita;Watanabe, Masahiko
• 通讯作者: Watanabe, Masahiko

新しい診断と治療のABC34「肺癌」(阿部庄作編)

新诊疗“肺癌”ABC34（阿部翔作编）

• 发表时间: 2012
• 作者: 早川和重;阿部庄作;早川和重(分担)
• 通讯作者: 早川和重(分担)

肺がんに対する化学放射線療法の新展開

肺癌放化疗新进展

• 发表时间: 2011
• 作者: 早田格;早川和重;新部譲;石山博條;小谷承子;関口茜衣;井川聡;三藤久;片桐真人;益田典幸;早川和重;早川和重;早川和重;早川和重;早川和重
• 通讯作者: 早川和重