Investigation of decline of neurocognitive function after cranial radiation therapy for brain tumors and exploring early diagnostic method

脑辐射后的不良辐射效应可导致严重的神经认知功能恶化。缺乏标准化的客观尺度来确定NCF下降的严重程度，这是研究预防和/或治疗这种疾病的方法的障碍。我们搭配了日本版的神经认知电池，与西方国家使用的电池兼容。在一项前瞻性研究中，该NCB在全脑放射治疗（WBRT）后4个月出现NCF恶化，8个月恢复，12个月下降。在弥散张量成像检查中，随着时间的推移，平均扩散率（MD）持续增加，这可能是判断白质损伤的一个潜在指标。在放疗后8个月，MD与基线相比的%差异幅度以胼胝体最大，其次是扣带。DTI和NCB的相关性有待进一步研究。

Adverse radiation effect after brain radiation may cause severe deterioration of neurocognitive function (NCF). The lack of standardized objective scale to determine the severity of the decline of NCF has been an obstacle to investigate the way to prevent and/or treat this condition. We assorted Japanese version of neurocognitive battery which is compatible to those used in Western countries. In a prospective study, this NCB demonstrated deterioration of NCF 4 months after whole-brain radiation therapy (WBRT), recovery at 8 months, and decline at 12 months. In the examination of diffusion tensor imaging, mean diffusivity (MD), which could be a potential index to determine the damage to white matter, continued to increase overtime. At 8 months after radiation, the magnitude of %difference of MD compared with baseline was greatest at corpus callosum followed by cingulate. The correlation of findings in DTI and NCB is a matter of further investigation.