The effect of oxygenated warm buffer perfusion with PGE1 before cold preservation on hepatic warm ischemia reperfusion injury

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The liver grafts which are taken from the donors after cardiac death(DCD)and preserved immediately in cold solution show bad function after transplantation. In this study, we perfused rat livers from DCD before cold preservation with oxygenated warm buffer containing Prostaglandin E1 and observed bile production, liver cell death, mitochondrial function of liver cell and so on during reperfusion with oxygenated buffer. In the result, these treatments improved liver function of the livers from DCD after reperfusion.