The enhancement of therapeutic efficacy of autologous cells by hypoxic preconditioning

通过植入自体细胞的治疗性血管生成是一种有前途的治疗缺血性疾病的方法。然而，植入缺血组织后细胞的保留差是与基于细胞的治疗潜力差相关的主要问题。这项研究表明，低氧预处理通过增加植入细胞的保留来增强其治疗潜力。这种方法是一种短期和简单的方法，增强植入细胞的血管生成能力。需要进一步的临床试验来证实这种方法的有效性。

Therapeutic angiogenesis by the implantation of autologous cells is a promising treatment for ischemic diseases. However, the poor retention of the cells after implantation into ischemic tissue is a major problem that related to poor potential of cell-based therapy. This study shows that hypoxic preconditioning enhances the therapeutic potential of implanted cells by increasing their retention. This approach is a short-term and simple method of enhancing the angiogenic potency of implanted cells. Further clinical trials are required to confirm the efficiency of this method.