Analysis of a novel BRCA1-associated protein for new cancer therapy

乳腺癌易感基因BRCA1的生殖系突变使女性易患乳腺癌和卵巢癌。BRCA 1在DNA修复和中心体调节中发挥重要作用，沿着其异源二聚体伴侣BARD 1。我们发现了一种与BARD 1相互作用的新蛋白质（在这里我们称之为BARD 1相互作用蛋白质（BIP））。我们发现BIP与BRCA 1和BARD 1一起在调节中心体扩增和胞质分裂中起重要作用。

Germline mutations in the breast cancer susceptibility gene BRCA1 predispose women to breast and ovarian cancers. BRCA1 plays important roles in DNA repair and centrosome regulation, along with its heterodimer partner BARD1. We identified a new protein that interacts with BARD1 (here we call it BARD1-interacting protein (BIP)). We found that BIP plays an important role in the regulation of centrosome amplification and cytokinesis together with BRCA1and BARD1.