Development of novel molecular targeted therapeutics that target the hypoxic environment of solid tumors

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Systemic administration of anticancer drugs may have serious side effects, and development of tumor-selective therapy is urgently needed. We investigated the clustering and antiproliferative effects of Lactobacillus casei, a lactobacillus, on solid tumors, based on the inside of a solid tumor being an aerobic environment compared with normal tissues. Bacterial strain KJ686, an obligate anaerobe, specifically clustered in solid tumors, but was eliminated from normal tissues. This strain may be useful as a tumor-selective delivery system that may have high therapeutic efficacy.