The clinical significance of ING2 expression in colorectal cancr

ING2在结直肠癌中表达的临床意义

• 批准号: 21591728
• 负责人: KUMAMOTO Kensuke
• 金额: $ 2.08万
• 依托单位: Fukushima Medical University (2013)Saitama Medical University (2009-2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591728/
• 关键词: 大腸癌; ING2; P53; p53

The biological significance of the ING2 gene expression in colon cancer will be clarified by in vitro experiments using colon cancer cell lines. The aim of this study is to develop the molecules target treatment in clinical practice. In immunohistochemical analysis of ING2 with 130 colorectal cancer, the strong staining was observed in 78 (60%) cases. Overexpression of ING2 induced MMP13 mRNA expression using a colon cancer cell line, HCT116, into which adenoviral ING2 expression vector was transfected, in cDNA microarray analysis. ING2 overexpressed cells acquired the ability of invasion, leading to suggest that enhanced ING2 expression in colorectal cancer might be associated with cellular invasion and metastasis. Weak expression of ING2 was associated with the effect of preoperative chemoradiotherapy for advanced lower rectal cancer. Therefore ING2 could be the useful marker for the effect of preoperative chemoradiotherapy for advanced lower rectal cancer.

ING2基因在结肠癌中表达的生物学意义将通过使用结肠癌细胞系的体外实验来阐明。本研究的目的是开发分子靶向治疗在临床实践中。130例结直肠癌组织中ING2的免疫组化分析，78例（60%）呈强阳性。将腺病毒介导的ING2表达载体转染结肠癌细胞系HCT 116，通过基因芯片分析，发现ING2的过表达可诱导MMP 13 mRNA的表达。ING2过表达的细胞获得了侵袭能力，提示ING2在结直肠癌中的表达增强可能与细胞的侵袭和转移有关。ING2的弱表达与进展期低位直肠癌术前放化疗效果相关。因此，ING2可作为晚期低位直肠癌术前放化疗疗效的参考指标。

项目成果

ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.

• DOI: 10.1002/ijc.24437
• 发表时间: 2009-09-15
• 期刊: International journal of cancer
• 影响因子: 6.4
• 作者: Kumamoto K;Fujita K;Kurotani R;Saito M;Unoki M;Hagiwara N;Shiga H;Bowman ED;Yanaihara N;Okamura S;Nagashima M;Miyamoto K;Takenoshita S;Yokota J;Harris CC
• 通讯作者: Harris CC

食道癌に対する放射線化学療法の効果予測因子としてのInhibitor of Growth2(ING2)

生长抑制剂 2 (ING2) 作为食管癌放化疗效果的预测因子

• 发表时间: 2011
• 作者: 中村泉;隈元謙介;ほか
• 通讯作者: ほか

ING2

英格2

• 发表时间: 2009
• 期刊: G.I. Research
• 作者: Onozato W;et al.;隈元謙介
• 通讯作者: 隈元謙介

当科におけるStageIV大腸癌の治療成績の検討

我科结直肠癌IV期治疗效果检查

• 发表时间: 2011
• 作者: 隈元謙介;石橋敬一郎;天野邦彦;桑原公亀;大澤智徳;岡田典倫;岩間毅夫;石田秀行
• 通讯作者: 石田秀行

Polymorphisms of GSTP1, ERCC2 and TS-3'UTR are associated with the clinical outcome of mFOLFOX6 in colorectal cancer patients.

• DOI: 10.3892/ol.2013.1467
• 发表时间: 2013-09
• 期刊: Oncology letters
• 影响因子: 2.9
• 作者: Kumamoto K;Ishibashi K;Okada N;Tajima Y;Kuwabara K;Kumagai Y;Baba H;Haga N;Ishida H
• 通讯作者: Ishida H