Application of endoscopic cell sheet transplantation for colorectal

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Based on clinical research of regenerative medical treatments using human oral mucosal epithelial cell sheets to prevent constriction after esophageal ESD, I conducted basic experiments on miniature pigs whereby cell sheets were applied to ulcerations caused by colorectal ESD. I conducted colorectal ESD on a miniature pig, followed by engraftment using fibroblast cell sheets. However, the isolated cells of the pig grew unstably. Therefore I decided to use oral mucosal cell sheets instead. The results of our study show that colorectal cell sheet transplantation is a good short-term treatment. It is possible that perforations can be repaired with cell sheets, decreasing the risk of complications. However, this possibility requires further study.