Liver repair and reconstitution of the hepatic sinusoids after acute liver injury

点击翻译按钮获取中文摘要

The failure of liver to regenerate is considered a critical contributing factor in liver dysfunction and liver failure after chemical, liver surgery, and inflammation. Hepatic tissue repair, including the reconstitution of hepatic microvasculature, plays a critical role in determining the final outcome of acutely injured liver. The present study was conducted to examine whether VEGF, a well-known angiogenic growth factor, and its receptor, VEGFR1, are involved in liver repair and regeneration. In the model of acute liver injury elicited by acetaminophen(APAP) and hepatic ischemia/reperfusion, VEGFR1 signaling plays an important role in liver repair and sinusoidal restoration after APAP hepatotoxicity and hepatic ischemia/reperfusion through the recruitment of macrophages expressing VEGFR1.