Evaluation of the synergistic anti-proliferation effects of heparin or NF-κB inhibitor and gemcitabine on pancreatic cancer

胰腺癌具有大量结缔组织框架的特点，癌细胞与结缔组织的相互作用可能对癌细胞的生长和侵袭非常重要，这在一定程度上导致了胰腺癌患者预后不良。我们评估了肝素或NF-κB抑制剂DHMEQ对胰腺癌的影响。肝素在体内模型上不仅具有抗增殖作用，而且具有抑制肝转移的作用。吉西他滨表现为抑制血管生成、诱导细胞凋亡和侵袭性抑制，而非抑制细胞生长。联合治疗的抗肿瘤效果良好。

Pancreatic cancer is characterized by abundant quantity of the connective tissue framework and the interaction between cancer cells and connective tissue could be very important for the growth and invasiveness of cancer cells, leading partly to the poor outcome of the patients with pancreatic cancer. We evaluated the effects of heparin or NF-κB inhibitor, DHMEQ, on pancreatic cancer. Heparin showed not only anti-proliferation effects but also inhibition of liver metastasis on in vivo model. Gemcitabine showed angiogenesis inhibition, apoptosis induction and invasiveness inhibition rather than cell growth inhibition. The anti-tumor effects of combination therapy were promising.