Identification of MicroRNA related to EMT of pancreas cancer, and elucidation of the miRNA control facility by Redox

胰腺癌 EMT 相关 MicroRNA 的鉴定及 Redox 阐明 miRNA 调控机制

• 批准号: 21591776
• 负责人: TAKAHATA Shunichi
• 金额: $ 2.91万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591776/
• 关键词: 膵臓外科学; 膵癌; EMT; miRNA; Redox

We analyzed over 100 surgical tissues of pancreatic cancer by using frozen sections. Several MicroRNA(miRNA) were identified as prognostic markers. Furthermore, we detected that precursor of miR-17-5p and that of miR-10b enhanced proliferation and invasion of pancreatic cancer cells. Meanwhile, we detected that precursor of miR-200c suppressed invasion of pancreatic cancer cells.

我们用冰冻切片分析了100多例胰腺癌手术组织。几种微小RNA（miRNA）被鉴定为预后标志物。此外，我们还检测到miR-17- 5 p和miR-10 b的前体可促进胰腺癌细胞的增殖和侵袭。同时检测到miR-200 c前体抑制胰腺癌细胞的侵袭能力。

项目成果

膵癌におけるマイクロRNA-200cの発現とその発現増強による浸潤能抑制効果

microRNA-200c在胰腺癌中的表达及其增强表达对侵袭能力的抑制作用

• 发表时间: 2009
• 作者: Tsutsumi K;Ohtsuka T;Sadakari Y;Nakata K;Ohuchida K;Takahata S;Mizumoto K;Tanaka M;余俊,大内田研宙,森山大樹,崔林,趙茗,佐藤典宏,水元一博,田中雅夫
• 通讯作者: 余俊,大内田研宙,森山大樹,崔林,趙茗,佐藤典宏,水元一博,田中雅夫

MicroRNA-203 expression as a new prognostic marker of pancreatic cancer(膵癌予後因子としてのmicroRNA-203)

MicroRNA-203表达作为胰腺癌新的预后标志物(microRNA-203 as a prognostic Factor for panclic cancer)

• 发表时间: 2010
• 作者: Murakami Y;Uemura K;Sudo T;et al.;池永直樹,大内田研宙,水元一博,坂井寛,田中雅夫
• 通讯作者: 池永直樹,大内田研宙,水元一博,坂井寛,田中雅夫

MicroRNA, has-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation

MicroRNA，has-miR-200c，是胰腺癌的独立预后因素，其上调可抑制胰腺癌侵袭，但会增加细胞增殖

• 发表时间: 2010
• 期刊: Molecular Cancer
• 影响因子: 37.3
• 作者: Yu J;Ohuchida K;Mizumoto K;Sato N;Kayashima T;Fujita H;Nakata K;Tanaka M
• 通讯作者: Tanaka M

Predictors of the presence of concomitant invasive ductal carcinoma in intraductal papillary neoplasm of the pancreas

胰腺导管内乳头状肿瘤并发浸润性导管癌的预测因素

• 发表时间: 2010
• 期刊: Ann Surg 251
• 作者: Ingkakul T;Sadakari Y;Ienaga J;Satoh N;Takahata S;Tanaka M.
• 通讯作者: Tanaka M.

MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis and involved in cancer cell proliferation and invasion

• DOI: 10.4161/cbt.10.8.13083
• 发表时间: 2010-10-15
• 期刊: CANCER BIOLOGY & THERAPY
• 影响因子: 3.6
• 作者: Yu, Jun;Ohuchida, Kenoki;Tanaka, Masao
• 通讯作者: Tanaka, Masao