Identification of MicroRNA related to EMT of pancreas cancer, and elucidation of the miRNA control facility by Redox
Identification of MicroRNA related to EMT of pancreas cancer, and elucidation of the miRNA control facility by Redox
批准号:
21591776
负责人:
TAKAHATA Shunichi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
我们用冷冻切片分析了100多个胰腺癌手术组织。几种MicroRNA(miRNA)被确定为预后标志物。此外,我们检测到miR-17-5p前体和miR-10b前体增强胰腺癌细胞的增殖和侵袭。同时,我们检测到miR-200c前体抑制胰腺癌细胞的侵袭。
英文摘要
We analyzed over 100 surgical tissues of pancreatic cancer by using frozen sections. Several MicroRNA(miRNA) were identified as prognostic markers. Furthermore, we detected that precursor of miR-17-5p and that of miR-10b enhanced proliferation and invasion of pancreatic cancer cells. Meanwhile, we detected that precursor of miR-200c suppressed invasion of pancreatic cancer cells.
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膵癌におけるマイクロRNA-200cの発現とその発現増強による浸潤能抑制効果
microRNA-200c在胰腺癌中的表达及其增强表达对侵袭能力的抑制作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Tsutsumi K, Ohtsuka T, Sadakari Y, Nakata K, Ohuchida K, Takahata S, Mizumoto K, Tanaka M, 余俊,大内田研宙,森山大樹,崔林,趙茗,佐藤典宏,水元一博,田中雅夫]
通讯作者:
余俊,大内田研宙,森山大樹,崔林,趙茗,佐藤典宏,水元一博,田中雅夫
MicroRNA-203 expression as a new prognostic marker of pancreatic cancer(膵癌予後因子としてのmicroRNA-203)
MicroRNA-203表达作为胰腺癌新的预后标志物(microRNA-203 as a prognostic Factor for panclic cancer)
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Murakami Y, Uemura K, Sudo T, et al., 池永直樹,大内田研宙,水元一博,坂井寛,田中雅夫]
通讯作者:
池永直樹,大内田研宙,水元一博,坂井寛,田中雅夫
MicroRNA, has-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation
MicroRNA,has-miR-200c,是胰腺癌的独立预后因素,其上调可抑制胰腺癌侵袭,但会增加细胞增殖
DOI:
--
发表时间:
2010
期刊:
Molecular Cancer
影响因子:
37.3
作者:
[Yu J, Ohuchida K, Mizumoto K, Sato N, Kayashima T, Fujita H, Nakata K, Tanaka M]
通讯作者:
Tanaka M
Predictors of the presence of concomitant invasive ductal carcinoma in intraductal papillary neoplasm of the pancreas
胰腺导管内乳头状肿瘤并发浸润性导管癌的预测因素
DOI:
--
发表时间:
2010
期刊:
Ann Surg 251
影响因子:
--
作者:
[Ingkakul T, Sadakari Y, Ienaga J, Satoh N, Takahata S, Tanaka M.]
通讯作者:
Tanaka M.
DOI:
10.4161/cbt.10.8.13083
发表时间:
2010-10-15
期刊:
CANCER BIOLOGY & THERAPY
影响因子:
3.6
作者:
[Yu, Jun, Ohuchida, Kenoki, Tanaka, Masao]
通讯作者:
Tanaka, Masao
共 18 条
Biomarkers in exosome extracted from duodenal fluid for early detection of pancreatobiliary malignancy
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批准号:18K08648
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2018
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负责人:TAKAHATA Shunichi
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依托单位:
Analysis of microRNAs associated with senescence during the progression of bile duct cancer.
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批准号:15K10186
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2015
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负责人:TAKAHATA Shunichi
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依托单位:
海外基金