Effectiveness of human atrial natriuretic for arrhythmia peptide after cardiac surgery

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We investigated whether infusion of human atrial natriuretic peptide (carperitide) could prevent postoperative atrial fibrillation.A total of 668 patients who underwent isolated coronary artery bypass grafting were randomized to receive infusion of carperitide or physiological saline from the initiation of cardiopulmonary bypass. Postoperative atrial fibrillation occurred in 41/335 patients (12.2%) from the carperitide group versus110/333 patients (32.7%) from the placebo group, and its incidence was significantly lower in the carperitide group. Carperitide could be a useful option for preventing postoperative atrial fibrillation.