Effectiveness of human atrial natriuretic for arrhythmia peptide after cardiac surgery

人心钠素对心脏手术后心律失常肽的疗效

• 批准号: 21591805
• 负责人: SEZAI Akira
• 金额: $ 0.67万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591805/
• 关键词: 心臓大血管外科学; 循環器・高血圧

We investigated whether infusion of human atrial natriuretic peptide (carperitide) could prevent postoperative atrial fibrillation.A total of 668 patients who underwent isolated coronary artery bypass grafting were randomized to receive infusion of carperitide or physiological saline from the initiation of cardiopulmonary bypass. Postoperative atrial fibrillation occurred in 41/335 patients (12.2%) from the carperitide group versus110/333 patients (32.7%) from the placebo group, and its incidence was significantly lower in the carperitide group. Carperitide could be a useful option for preventing postoperative atrial fibrillation.

为探讨心钠素（carperitide）对体外循环术后心房颤动的预防作用，将668例接受离体冠状动脉旁路移植术的患者随机分为两组，每组10例。卡培立肽组41/335例患者（12.2%）发生术后房颤，安慰剂组110/333例患者（32.7%）发生术后房颤，卡培立肽组的发生率显著较低。卡培立肽可能是预防术后房颤的有效选择。

项目成果

Long-Term Results (Three-Year)of Emergency Comergency Coronary Artery Bypass Grafting for Patients With Unstable Angina Pectoris

不稳定型心绞痛患者急诊冠状动脉搭桥术的长期结果（三年）

• 发表时间: 2010
• 期刊: The American Journal of Cardiology
• 作者: Sezai A,Hata M;Niino T;Yoshitake I;Unosawa S;Wakui S;Fujita K;Takayama T;Kasamaki Y;Hirayama A;Minami K;Sezai A
• 通讯作者: Sezai A

Continuous low-dose infusion of human atrial natriuretic peptide in patients with left ventricular dysfunction undergoing coronary artery bypass grafting : The NU-HIT trial for LVD

对接受冠状动脉旁路移植术的左心室功能障碍患者持续低剂量输注人心钠肽：针对 LVD 的 NU-HIT 试验

• 发表时间: 2010
• 期刊: Journal of American College of Cardiology (in press)
• 作者: Sezai A,Hata M;Niino T;Yoshitake I;Unosawa S;Wakui S;Fujita K;Takayama T;Kasamaki Y;Hirayama A;Minami K;Sezai A;Sezai A;Sezai A
• 通讯作者: Sezai A

Efficacy of Beta-blockers in the Prevention of Atrial Fibrillation after Coronary Artery Bypass Grafting

β-受体阻滞剂预防冠状动脉搭桥术后心房颤动的功效

• 发表时间: 2012
• 作者: 瀬在明,中井俊子;秦光賢;吉武勇;木 村玄;畑博明;塩野元美;國本聡;笠巻 祐二;平山篤志;瀬在明
• 通讯作者: 瀬在明

長期予後を期待した慢性腎臓病(CKD)合併症例に対する術中・術後治療法-NU-HIT trial for CKD-

期待长期预后的慢性肾脏病（CKD）并发症的术中和术后治疗方法 -NU-HIT CKD 试验 -

• 发表时间: 2010
• 作者: 瀬在明,畑博明;秦光賢;飯田充;吉武勇;宇野澤聡;和久井真司;猪野崇;木村玄;塩野元美;瀬在明
• 通讯作者: 瀬在明

NU-HIT trial から得られたhANP治療の有効性

从 NU-HIT 试验中获得的 hANP 治疗的疗效

• 发表时间: 2010
• 作者: 瀬在明,南和友;秦光賢;吉武勇;高坂彩子;木村玄;村上朝彦;塩野元美;高山忠輝;平山篤志;瀬在明;瀬在明;瀬在明;瀬在明
• 通讯作者: 瀬在明