Improvement of functional recovery and promotion of remyelination by cell transplantation and scaffold at the chronic phase after spinal cord injury

本研究将神经祖细胞（NPCs）或骨髓基质细胞（BMCs）与蜂窝状胶原支架（HC）联合移植到损伤脊髓内。在初次胸椎损伤后6周，将带有npc的HC植入挫伤脊髓。两个移植组的功能恢复都不明显。另一方面，在半切模型中，植入含有bmc的HC的大鼠的后肢功能和超敏反应优于未植入bmc的HC。植入区域比不含bmc的区域显示出更多的神经纤维。这些作用是由于bmc的存在直接促进了神经再生。然而，大多数脊髓损伤患者已经瘫痪并维持到慢性恢复期。需要进一步的治疗，如切除瘢痕组织、发展移植技术或康复，以促进脊髓损伤后慢性期的功能恢复。

In this study, neural progenitor cells(NPCs) or bone marrow stromal cells(BMCs) combined with honeycomb collagen scaffold(HC) were transplanted into the injured spinal cord. HC with NPCs were implanted into contused spinal cord at six weeks after the initial thoracic injury. The functional recovery was little shown in the both implanted groups. On the other hand, rats implanted with HC containing BMCs displayed better hindlimb function and hypersensitivity than those implanted with HC without BMCs in the hemisected model. The implanted area exhibited more nerve fibers than the areas not containing BMCs. These effects result from the presence of BMCs that directly promote nerve regeneration. However, most of spinal cord injury patients have already paralyzed and maintained into chronic phase of recovery. Further treatments such as resection of scar tissue, developments of transplantation technique or rehabilitation would be needed to promote functional recovery at the chronic phase after spinal cord injury.