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From analysis of osteopontin function to development of preventive and medical treatment for osteoporosis.

From analysis of osteopontin function to development of preventive and medical treatment for osteoporosis.
从骨桥蛋白功能分析到骨质疏松症预防和治疗的发展。
批准号:
21591951
负责人:
HIGUCHI Yasunori
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
We generated transgenic(OPN-TG) mice expressing osteopontin(OPN) which is a phosphoglycoprotein secreted by osteoblasts mainly. We found that an increase of calcium and type I collagen cross linked N teropeptide(NTx) in serum of OPN-TG mice, compared with normal mice. OPN-TG mice showed a decrease of bone density obtained by QCT and so is a useful model of human osteoporosis. Furthermore, we need in vitro analysis of the bone marrow cells with OPN-related proteins or peptides.
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DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [片岡晶志, 樋口安典, 津村弘]
通讯作者: 津村弘
Mechanisms ofpromoting the bone invasion of cancer cells by osteopontin
  • 批准号:
    18592190
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.57万
  • 财政年份:
    2006
  • 负责人:
    HIGUCHI Yasunori
  • 依托单位:
In vivo analysis of osteopontin function
  • 批准号:
    08457074
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $4.74万
  • 财政年份:
    1996
  • 负责人:
    HIGUCHI Yasunori
  • 依托单位:
Fundamental studies of regularion for endotoxin shock by CD14
  • 批准号:
    05557057
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research (B)
  • 资助金额:
    $11.58万
  • 财政年份:
    1993
  • 负责人:
    HIGUCHI Yasunori
  • 依托单位:
Molecular pathology of osteopontin transgenic mice
  • 批准号:
    06454194
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
  • 资助金额:
    $4.61万
  • 财政年份:
    1993
  • 负责人:
    HIGUCHI Yasunori
  • 依托单位:
海外基金