From analysis of osteopontin function to development of preventive and medical treatment for osteoporosis.
From analysis of osteopontin function to development of preventive and medical treatment for osteoporosis.
批准号:
21591951
负责人:
HIGUCHI Yasunori
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We generated transgenic(OPN-TG) mice expressing osteopontin(OPN) which is a phosphoglycoprotein secreted by osteoblasts mainly. We found that an increase of calcium and type I collagen cross linked N teropeptide(NTx) in serum of OPN-TG mice, compared with normal mice. OPN-TG mice showed a decrease of bone density obtained by QCT and so is a useful model of human osteoporosis. Furthermore, we need in vitro analysis of the bone marrow cells with OPN-related proteins or peptides.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
オステオポンチンが破骨細胞に及ぼす影響-オステオポンチントランスジェニックマウスの解析-
骨桥蛋白对破骨细胞的作用-骨桥蛋白转基因小鼠分析-
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[片岡晶志, 樋口安典, 津村弘]
通讯作者:
津村弘
Mechanisms ofpromoting the bone invasion of cancer cells by osteopontin
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批准号:18592190
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
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负责人:HIGUCHI Yasunori
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依托单位:
In vivo analysis of osteopontin function
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批准号:08457074
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.74万
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财政年份:1996
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负责人:HIGUCHI Yasunori
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依托单位:
Fundamental studies of regularion for endotoxin shock by CD14
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批准号:05557057
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$11.58万
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财政年份:1993
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负责人:HIGUCHI Yasunori
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依托单位:
Molecular pathology of osteopontin transgenic mice
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批准号:06454194
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.61万
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财政年份:1993
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负责人:HIGUCHI Yasunori
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依托单位:
Regulation and analysis of systemic and local effect of TNF
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批准号:04454189
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1992
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负责人:HIGUCHI Yasunori
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依托单位:
海外基金