The mechanism and prevension method of steroid-induced osteonecrosis from the view point of oxidative stress.

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We performed investigation of steroid-induced osteonecrosis at the view of oxidative stress.We reported the possibility of prevention of steroid-induced osteonecrosis by administration of antioxidant Vitamin E in a rabbit model.We reported that Oxidative stress induced osteonecrosis in rats. This model is a novel and simple. We hope this rat model is very useful for investigation of mechanism of osteonecrosis in the near future.Using rat osteonecrosis model, the ischemic event in bone occurred within 6 hours after BSO administration.