Cell biological analysis of the effect of hypoxia-induced gene expressions on progression of pulmonary alveolar inflammation

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Systemic shock manifested as a symptom of sepsis and tabaco smoking disturb physiological homeostasis and induces phothophysiological changes in epithelium, interstitial tissue and capillary vessels of pulmonary alveoli as a unit of gas exchange. To review these pathological phenomena from the point of signal transduction and gene expression elicited by systemic and tissue hypoxia and understand molecular mechanisms behind the phenomena, we analysed cells and mice adopting methodology of molecular biology in relation to hypoxia-inducible factor 1 activity.