Line Scan Diffusion MR Spectrum of Edema in the Rat skeletal Muscle of Neuropathic model

在神经病理性疼痛动物模型和失神经肌肉中，我们可以利用弥散磁共振检测到病变骨骼肌中极早期的水肿性改变。T2比值逐渐升高，CRPS模型在3周达到峰值，失神经模型在4周达到峰值。ADC比率在两种模型中均在术后1天开始升高，1周后开始下降，而绝对值在失神经模型中更高。AQ4单抗染色显示失神经模型组AQ4发生率略高。磁共振弥散成像是发现CRPS患肢早期水肿性改变的有用工具。

We could detect the extremely early edematous changes in the affected skeletal muscle in the neuropathic pain animal model and in the denervated muscle using diffusion MRI. T2 ratios increased gradually with a peak at three weeks in CRPS model and 4 weeks in denervated model. ADC ratios jumped up at one day after the surgery and began to decrease at one week in both models, while absolute ratio is much higher in denervated model. AQ4 monoclonal antibody staining indicated that slightly higher incidence of AQ4 in denervated model. Diffusion MRI can be a useful tool to detect the early edematous change of CRPS affected limbs.