The study on the molecular mechanisms of development of endometriosis and estrogen-dependent gynecologic cancer

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The expression of DBC1(deleted in breast cancer 1), a putative tumor-suppressor gene, negatively regulates the ligand-dependent transcriptional activation function of ERβwhich appears to protect against the mitogenic effect of estrogen in breast tissue. The expression of DBC1 also represses the transcriptional activation function of BRCT and inhibits the transactivation of SIRT1 promoter mediated by BRCA1. In contrast, the expression of TFII-I, a multifunctional transcriptional factor, stimulates the transcriptional activation function of BRCT and enhances the transactivation of SIRT1 promoter mediated by BRCA1. These results suggest that DBC1 may be tumorigenic and TFII-I may be antitumorigenic, and have important implications to understand the development of breast cancer. In epithelial ovarian cancer, SNP array and DNA microarray reveal that chromosomal instability and gene expression profiles depend on the histological type, which may serve as a reference to determine a treatment strategy.