Inhibition of cell proliferation of human endometriotic cells by parthenolide

本研究的目的是探讨芹菜素（类黄酮）和孤雌酚内酯（植物小白菊）作为子宫内膜异位症可能的治疗剂的有效性。(1)芹菜素抑制子宫内膜异位症基质细胞（ESCs）的有丝分裂活性和PGE2合成。(2)用parthenolide预处理，TNF。-诱导的IL-8表达在ESCs中受到抑制。肿瘤坏死因子。-诱导的COX-2表达和PGE2合成也受到抑制。Parthenolide通过抑制NF抑制ESCs的增殖。采用小鼠子宫内膜异位症模型，给予parthenolide可显著减少子宫内膜异位症病变。

The aim of this study was to investigate the usefulness of apigenin(flavonoid) and parthenolide(plant feverfew) as a possible therapeutic agent for endometriosis.(1) Apigenin suppressed mitogenic activity and PGE2 synthesis in endometriotic stromal cells(ESCs).(2) With parthenolide pretreatment, TNF.-induced IL-8 expression were repressed in ESCs. TNF.-induced COX-2 expression and PGE2 synthesis were also inhibited. Parthenolide suppressed ESCs proliferation by inhibition of NF. B pathway, Using the murine endometriosis model, administrating parthenolide significantly reduced the endometriotic lesions.