Analysis of the lipoxygenase and its signaling pathway involved in the pathophysiology of endometriosis

本研究的目的是阐明溶氧酶（LOX）及其信号通路在子宫内膜异位症发病机制和病理生理中的作用。我们证明，与正常异位子宫内膜相比，子宫内膜瘤中5-LOX和15-LOX mRNA水平上调，而12-LOX mRNA水平在两者之间没有差异。这些结果共同表明，LOX途径可能至少部分参与了子宫内膜异位症的病理生理。我们还以严重免疫缺陷小鼠为研究工具，建立了几种类型的子宫内膜异位症小鼠体内模型，探索LOX及其信号通路在子宫内膜异位症中的作用。

The purpose of this research project was to elucidate the role of the lypoxygenase(LOX) and its signaling pathway in the pathogenesis and pathophysiology of endometriosis. We demonstrated that 5-LOX and 15-LOX mRNA were up-regulated in endometrioma compared to normal eutopic endometrium, whereas 12-LOX mRNA levels did not differ between them. These results collectively suggest that the LOX pathway may be, at least in part, involved in the pathophysiology of endometriosis. We have also developed several types of in vivo mouse model of endometrisois using severely immunodeficient mice as a research tool to explore the role of LOX and its signaling pathway in endometriosis.