Analysis of the lipoxygenase and its signaling pathway involved in the pathophysiology of endometriosis

子宫内膜异位症病理生理中脂氧合酶及其信号通路分析

• 批准号: 21592110
• 负责人: YAMASAKI Akiko
• 金额: $ 2.91万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592110/
• 关键词: 子宮内膜症; 疼痛; リポキシゲナーゼ; ロイコトリエン; リポキシン; 脂質メディエーター; リポキシゲナーゼ類

The purpose of this research project was to elucidate the role of the lypoxygenase(LOX) and its signaling pathway in the pathogenesis and pathophysiology of endometriosis. We demonstrated that 5-LOX and 15-LOX mRNA were up-regulated in endometrioma compared to normal eutopic endometrium, whereas 12-LOX mRNA levels did not differ between them. These results collectively suggest that the LOX pathway may be, at least in part, involved in the pathophysiology of endometriosis. We have also developed several types of in vivo mouse model of endometrisois using severely immunodeficient mice as a research tool to explore the role of LOX and its signaling pathway in endometriosis.

本研究的目的是阐明溶氧酶（LOX）及其信号通路在子宫内膜异位症发病机制和病理生理中的作用。我们证明，与正常异位子宫内膜相比，子宫内膜瘤中5-LOX和15-LOX mRNA水平上调，而12-LOX mRNA水平在两者之间没有差异。这些结果共同表明，LOX途径可能至少部分参与了子宫内膜异位症的病理生理。我们还以严重免疫缺陷小鼠为研究工具，建立了几种类型的子宫内膜异位症小鼠体内模型，探索LOX及其信号通路在子宫内膜异位症中的作用。

项目成果

Contribution of myometrial stem/progentior cells to pregnancy-induced uterine remodeling

子宫肌层干/祖细胞对妊娠诱导的子宫重塑的贡献

• 发表时间: 2011
• 作者: Masanori Ono;Tetsuo Maruyama Takashi Kajitani;Hiroshi Uchida Hideyuki Oda;Sayaka Uchida;Toru Arase;Akiko Yamasaki;Takashi Nagashima;Hirotaka Masuda;Yasunori Yoshimura
• 通讯作者: Yasunori Yoshimura

ミニ・シンポジウム2「子宮内膜幹細胞と子宮内膜症」

小型研讨会2“子宫内膜干细胞与子宫内膜异位症”

• 发表时间: 2011
• 期刊: 第1回Asian Conference on Endometriosis Mini-symposium : Endometriosisi reseach in Japan Prog.Med.別刷り
• 作者: A. Miyamoto;et al.;田中栄;丸山哲夫
• 通讯作者: 丸山哲夫

Identification of a novel endometrial gene associated with menstruation, endometriosis and adenomyosis

鉴定与月经、子宫内膜异位症和子宫腺肌病相关的新型子宫内膜基因

• 发表时间: 2011
• 作者: Tetsuo Maruyama;Takashi Kajitani;Hideyuki Oda;Kaoru Miyazaki;Sayaka Uchida;Akiko Yamasaki;Hironori Asada;Hiroshi Uchida;Yasunori Yoshimura
• 通讯作者: Yasunori Yoshimura

腹水と血清中における代謝物質の網羅的分析による子宮内膜症特異的な代謝物質の探索

通过腹水和血清代谢物的综合分析寻找子宫内膜异位症特异性代谢物

• 发表时间: 2010
• 期刊: 日本エンドメトリオーシス学会会誌 31巻
• 作者: Hachisuka J;et al.;川田陽子,島田友恵,浅田弘法,杉本昌弘,平山明由,阿部しのぶ,古谷正敬,内田浩,浜谷敏生,梶谷宇,丸山哲夫,久慈直昭,吉村泰典,曽我朋義,冨田勝
• 通讯作者: 川田陽子,島田友恵,浅田弘法,杉本昌弘,平山明由,阿部しのぶ,古谷正敬,内田浩,浜谷敏生,梶谷宇,丸山哲夫,久慈直昭,吉村泰典,曽我朋義,冨田勝

Stem cells theory for the pathogenesis of endometriosis

子宫内膜异位症发病机制的干细胞理论

• 发表时间: 2011
• 作者: Hiroshi Uchida;Tetsuo Maruyama;Sayaka Uchida-Nishikawa;Yasunori Yoshimura;Tetsuo Maruyama
• 通讯作者: Tetsuo Maruyama