Analyzing how defects of Mitochondria DNA affect oocyte maturation.

分析线粒体 DNA 缺陷如何影响卵母细胞成熟。

• 批准号: 21592117
• 负责人: YAMASHITA Yoshiki
• 金额: $ 2.5万
• 依托单位: Osaka Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592117/
• 关键词: 生殖医学; ミトコンドリア; 不妊症; 顆粒膜細胞; 抗ミュラー管ホルモン(AMH); AMHレセプタ; 一塩基多型(SNP); mtDNA4677; real time PCR; 妊馬血ゴナドトロピン; ラットの顆粒膜細胞; IVF-ET; hMG; recFSH

SNP of AMH rather than mitochondria DNA defect might affect the infertility caused by the older age. The influence of AMH-SNP on infertility was not apparent, however, SNP of AMHR(AMHRII-482A> G、、ISV 5-6C> T, ISV10+77A> G) might cause infertility due to ovarian failure involving lower number of retrieved oocyte and fertilization rate. Especially,-482A> G polymorphysm is thought to be associated with diminished ovarian failure.

AMH的SNP而不是线粒体DNA缺陷可能是老年不孕症的影响因素。AMH-SNP对不孕症的影响不明显，AMHR(AMHRII-482A&GT；G、、ISV5-6C&GT，ISV10+77A&GT；G)单核苷酸多态可能导致卵巢衰竭所致的不孕不育，导致获卵数和受精率降低。尤其是-482a&gt；G基因多态被认为与减少卵巢功能衰竭有关。

项目成果

MTX could be First-Line Therapy Even in Cases where hCG Level is Greater than 5,000 IU/ml

即使 hCG 水平高于 5,000 IU/ml，MTX 也可以成为一线治疗

• 发表时间: 2012
• 期刊: Ectopic pregnancy Modern Diagnosis and Management
• 作者: Yoshiki Yamashita;Sousuke Katoh;Yoko Yoshida;Satoe Fujiwara;Sachiko Kawabe;Mika Hayashi;Atsushi Hayashi;Yoshito Terai;Masahide Ohmichi
• 通讯作者: Masahide Ohmichi

体外受精治療下黄体化顆粒膜細胞におけるBMP15, GDF9 mRNAの発現の臨床的検討

IVF治疗黄素化颗粒细胞中BMP15和GDF9 mRNA表达的临床研究

• 发表时间: 2012

体外受精治療下黄体化顆粒膜細胞におけるBMP15,GDF9 mRNAの発現の臨床的検討

IVF治疗黄素化颗粒细胞中BMP15和GDF9 mRNA表达的临床研究

• 发表时间: 2012
• 作者: 川辺紗智子;吉田陽子;山下能毅;林篤史;林美佳;林正美;大道正英
• 通讯作者: 大道正英

Remarkable Lethal G-to-A Mutations in vif-Proficient HIV-1 Provirus by Individual APOBEC3 Proteins in Humanized Mice

• DOI: 10.1128/jvi.00823-10
• 发表时间: 2010-09-15
• 期刊: JOURNAL OF VIROLOGY
• 影响因子: 5.4
• 作者: Sato, Kei;Izumi, Taisuke;Koyanagi, Yoshio
• 通讯作者: Koyanagi, Yoshio

Topotecan as a molecular targeting agent which blocks the Akt and VEGF cascade in platinum-resistant ovarian cancers

• DOI: 10.4161/cbt.10.11.13443
• 发表时间: 2010-12
• 期刊: Cancer Biology & Therapy
• 影响因子: 3.6
• 作者: Satoshi Tsunetoh;Y. Terai;H. Sasaki;Akiko Tanabe;Yoshimichi Tanaka;Tatsuharu Sekijima;Satoe Fujioka;Hiroshi Kawaguchi;M. Kanemura;Y. Yamashita;M. Ohmichi