课题基金 / 基金详情

Analysis of immunosuppressive microenvironment associated with Epithelial-Mesenchymal Transition in uterine cancer.

Analysis of immunosuppressive microenvironment associated with Epithelial-Mesenchymal Transition in uterine cancer.
与子宫癌上皮间质转化相关的免疫抑制微环境分析。
批准号：
21592144
负责人：
FUJITA Tomonobu
金额：
$2.91万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592144/
关键词：
癌子宮体癌子宮頚癌EMT免疫抑制上皮間葉転換

项目摘要

项目成果

FUJITA Tomonobu的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
To analyze immunosuppressive tumor microenvironment associated with EMT, novel cancer-associated genes MYEOV and HOXD9 were investigated. After the transfection of MYEOV siRNA into the endometrial cancer cell lines, migration index and invasion index were both significantly lower than that in the control group. mRNA expression of Snail1, Snail2, ZEB1 was significantly reduced, while fibronectin was significantly increased. Silencing of HOXD9 inhibits cell proliferation in 4 of 4 cervical cancer cells, but there were no EMT related gene that was commonly inhibited nor stimulated in 4 cervical cell lines.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
RNA Helicase Encoded by Melanoma Differentiation-Associated Gene 5 Is a Major Autoantigen in Patients With Clinically Amyopathic Dermatomyositis Arthritis Rheum
黑色素瘤分化相关基因 5 编码的 RNA 解旋酶是临床无肌病性皮肌炎关节炎大黄患者的主要自身抗原
DOI： --
发表时间： 2009
期刊：
影响因子： --
作者： [Sato S, Hoshino K, Satoh T, Fujita T, Kawakami Y, Fujita T, Kuwana M]
通讯作者： Kuwana M
RNA Helicase Encoded by Melanoma Differentiation-Associated Gene 5 Is a Major Autoantigen in Patients With Clinically Amyopathic Dermatomyositis.
由黑色素瘤分化相关基因 5 编码的 RNA 解旋酶是临床无肌病性皮肌炎患者的主要自身抗原。
DOI： --
发表时间： 2009
期刊： Arthritis Rheum. 60(7)
影响因子： --
作者： [Sato S, et al.]
通讯作者： et al.
Blockade of activated NF-kB in cancer and immune cells mayeliminate immunosuppressive state in human ovarian cancer
阻断癌症和免疫细胞中活化的 NF-kB 可能消除人类卵巢癌的免疫抑制状态
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Hiroshi Nishio, Tomonori Yaguchi, Tomonobu Fujita, Kazuo Umezawa, Takashi Iwata, Takuma Fujii, Hidetoshi Sumimoto, Daisuke Aoki, Yutaka Kawakami]
通讯作者： Yutaka Kawakami
Epithelial Mesenchymal Transition in Human Ocular Chronic Graft-Versus-Host Disease
DOI： 10.2353/ajpath.2009.090318
发表时间： 2009-12-01
期刊： AMERICAN JOURNAL OF PATHOLOGY
影响因子： 6
作者： [Ogawa, Yoko, Shimmura, Shigeto, Tsubota, Kazuo]
通讯作者： Tsubota, Kazuo
共 11 条
    Immunosuppressive roles of HNF-1beta in ovarian clear cell carcinoma (OCCC)
    • 批准号：
      24592532
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.49万
    • 财政年份：
      2012
    • 负责人：
      FUJITA Tomonobu
    • 依托单位：
      Keio University
    Development of new treatment for endometrial cancer based on theanalysis of immune suppressive molecules
    • 批准号：
      19591944
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.91万
    • 财政年份：
      2007
    • 负责人：
      FUJITA Tomonobu
    • 依托单位：
      Keio University
    Identification of new cervical cancer antigens by SEREX using sera from cervical cancer tissue transplanted SCID mice
    • 批准号：
      16591687
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $1.98万
    • 财政年份：
      2004
    • 负责人：
      FUJITA Tomonobu
    • 依托单位：
      Keio University
    Systemic identification of mutated proteins with frame-shifted from MSI positive colon carcinoma
    • 批准号：
      14571226
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.11万
    • 财政年份：
      2002
    • 负责人：
      FUJITA Tomonobu
    • 依托单位：
      KEIO UNIVERSITY
    海外基金