Identification of differentially expressed microRNAs in head and neck squamous cell carcinoma based on microRNA expression signature

基于microRNA表达特征鉴定头颈鳞状细胞癌中差异表达的microRNA

• 批准号: 21592187
• 负责人: SEKI Naohiko
• 金额: $ 3万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592187/
• 关键词: 癌; マイクロRNA; 機能性核酸; 癌抑制遺伝子; 頭頸部扁平上皮癌; 機能性RNA; 頭頚部扁平上皮癌

MicroRNAs (miRNAs) are endogenous short non-coding RNA molecules that regulate gene expression by repressing translation or cleaving RNA transcripts in a sequence-specific manner. A growing body of evidence suggests that miRNAs are aberrantly expressed in many human cancers and that they play significant roles in the initiation, development and metastasis of human cancers. Recently, our expression profile revealed that microRNA-1, microRNA-133a and microRNA-375 are frequently downregulated in head and neck squamous cell carcinoma (HNSCC). Ectopic expression of three miRNAs (microRNA-1, microRNA-133a and microRNA-375) inhibited cell growth, migration and invasion of HNSCC cells, suggesting these microRNAs function as tumor suppressors in HNSCC.

MicroRNAs （miRNAs）是内源性短的非编码RNA分子，通过抑制翻译或以序列特异性的方式切割RNA转录物来调节基因表达。越来越多的证据表明，mirna在许多人类癌症中异常表达，并在人类癌症的发生、发展和转移中发挥重要作用。最近，我们的表达谱显示，microRNA-1、microRNA-133a和microRNA-375在头颈部鳞状细胞癌（HNSCC）中经常下调。异位表达3种mirna （microRNA-1、microRNA-133a和microRNA-375）可抑制HNSCC细胞的生长、迁移和侵袭，提示这些mirna在HNSCC中具有抑瘤作用。

项目成果

miR-133aas a tumor suppressive microRNA targeting multiple oncogenes in head neck squamous cell carcinoma.

miR-133a 作为一种肿瘤抑制性 microRNA，针对头颈鳞状细胞癌中的多个癌基因。

• 发表时间: 2011
• 作者: Oridate N,;他;岡野光博;Nohata N.
• 通讯作者: Nohata N.

Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma

• DOI: 10.3892/ijo_00000840
• 发表时间: 2011-01-01
• 期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
• 影响因子: 5.2
• 作者: Nohata, Nijiro;Hanazawa, Toyoyuki;Seki, Naohiko
• 通讯作者: Seki, Naohiko

Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma

• DOI: 10.3892/ijo.2011.1096
• 发表时间: 2011-11-01
• 期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
• 影响因子: 5.2
• 作者: Nohata, Nijiro;Hanazawa, Toyoyuki;Seki, Naohiko
• 通讯作者: Seki, Naohiko

Identification of tumor suppressive microRNAs in maxillary sinus squamous cell carcinoma based on microRNA expression signature

基于microRNA表达特征鉴定上颌窦鳞状细胞癌中的抑癌microRNA

• 发表时间: 2011
• 作者: Toyoyuki Hanazawa;Nijiro Nohata;Naoko Kikkawa;Akihiro Katayama;Yasuaki Harabuchi;Yoshitaka Okamoto;Naohiko Seki
• 通讯作者: Naohiko Seki

Tumor suppressive microRNA-375 targeting multiple oncogenes in maxillary sinus squamous cell carcinoma (MSSCC)

靶向上颌窦鳞状细胞癌 (MSSCC) 多种癌基因的抑癌 microRNA-375

• 发表时间: 2011
• 作者: Takashi Kinoshita;Nijiro Nohata;Toyoyuki Hanazawa;Naoko Kikkawa;Mutallip Muradil;Hirofumi Yoshino;Kazumori Kawakami;Takeshi Chiyomaru;Hideki Enokida;Masayuki Nakagawa;Yoshitaka Okamoto;Naohiko Seki
• 通讯作者: Naohiko Seki