EFFECTS OF THE ARMS2 GENE POLYMORPHISM ON CLINICAL FEATURES OF RETINITIS PIGMENTOSA

Arms2基因多态性对色素性视网膜炎临床特征的影响

• 批准号: 21592213
• 负责人: NAKAZAWA Mitsuru
• 金额: $ 2.91万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592213/
• 关键词: 臨床; 眼科学; 遺伝性網膜変性; 網膜色素変性; 加齢黄斑変性; 視細胞; アポトーシス; ARMS1遺伝子; ミトコンドリア

I studied the effects of the ARMS2 gene polymorphism, which was known to be related to age-related macular degeneration, on the clinical severities of retinitis pigmentosa to clarify whether this polymorphism also might act as a modifier of retinitis pigmentosa. Under the approval of the committee of ethics for clinical study of Hirosaki University, I analyzed the ARMS2 polymorphism of the patients with retinitis pigmentosa at the Hirosaki University Hospital, and examined the relationship between the types of the ARMS2 polymorphism (Ala69Ser) and progression of visual field constriction evaluated by the MD slope of Humphry's 10-2 program. The results obtained revealed that there was no co-relationship between ARMS2 polymorphisms and MD slopes. These results suggest that the ARMS2 polymorphism (Ala69Ser) may not play as a modifier of the central visual field constriction in patients with retinitis pigmentosa.

我研究了已知与年龄相关性黄斑变性有关的ARMS2基因多态性对视网膜色素变性临床严重性的影响，以澄清该基因多态性是否也可能作为视网膜色素变性的修饰物。在Hirosaki大学临床研究伦理委员会的批准下，我分析了Hirosaki大学医院视网膜色素变性患者的ARMS2基因多态性，并用Humphry‘s 10-2程序的MD斜率评估了ARMS2基因多态性类型(Ala69Ser)与视野收缩进展的关系。结果表明，ARMS2基因多态性与MD斜率无相关性。这些结果提示，ARMS2多态(Ala69Ser)可能不是视网膜色素变性患者中心视野收缩的调节因子。

项目成果

Effect of Nilvadipine on Central Visual Field in Retinitis Pigmentosa: A 30-Month Clinical Trial

• DOI: 10.1159/000320500
• 发表时间: 2011-01-01
• 期刊: OPHTHALMOLOGICA
• 影响因子: 2.6
• 作者: Nakazawa, Mitsuru;Ohguro, Hiroshi;Metoki, Tomomi
• 通讯作者: Metoki, Tomomi

内境界膜自然剥離を伴った黄斑円孔症例

黄斑裂孔伴自发性内界膜脱离一例

• 发表时间: 2009
• 期刊: あたらしい眼科 26
• 作者: 伊藤忠、目時友美;他
• 通讯作者: 他

涙液.眼科医にも分かる生理活性物質と眼疾患の基礎26

泪液：眼科医生也了解的生理活性物质和眼部疾病的基础知识 26

• 发表时间: 2012
• 期刊: 臨床眼科
• 作者: SATO Kiminori;UMENO Hirohito;NAKASHIMA Tadashi;羽生昇;中澤満
• 通讯作者: 中澤満

Epidermal nevus syndrome associated with anterior scleral staphyloma and ectopic bone and cartilaginous intraocular tissue

伴有前巩膜葡萄肿和异位骨及软骨眼内组织的表皮痣综合征

• 发表时间: 2010
• 期刊: Jpn J Ophthalmol
• 影响因子: 2.4
• 作者: Miyagawa Y;Nakazawa M;Kudoh T
• 通讯作者: Kudoh T

視細胞保護の分子薬理

光感受器保护的分子药理学

• 发表时间: 2011
• 作者: Kayama M;Nakazawa T;Thanos A;Morizane Y;Murakami Y;Theodoropoulos S;Abe T;Vavvas D;Miller JW;中澤満
• 通讯作者: 中澤満