EFFECTS OF THE ARMS2 GENE POLYMORPHISM ON CLINICAL FEATURES OF RETINITIS PIGMENTOSA

我研究了已知与年龄相关性黄斑变性有关的ARMS2基因多态性对视网膜色素变性临床严重性的影响，以澄清该基因多态性是否也可能作为视网膜色素变性的修饰物。在Hirosaki大学临床研究伦理委员会的批准下，我分析了Hirosaki大学医院视网膜色素变性患者的ARMS2基因多态性，并用Humphry‘s 10-2程序的MD斜率评估了ARMS2基因多态性类型(Ala69Ser)与视野收缩进展的关系。结果表明，ARMS2基因多态性与MD斜率无相关性。这些结果提示，ARMS2多态(Ala69Ser)可能不是视网膜色素变性患者中心视野收缩的调节因子。

I studied the effects of the ARMS2 gene polymorphism, which was known to be related to age-related macular degeneration, on the clinical severities of retinitis pigmentosa to clarify whether this polymorphism also might act as a modifier of retinitis pigmentosa. Under the approval of the committee of ethics for clinical study of Hirosaki University, I analyzed the ARMS2 polymorphism of the patients with retinitis pigmentosa at the Hirosaki University Hospital, and examined the relationship between the types of the ARMS2 polymorphism (Ala69Ser) and progression of visual field constriction evaluated by the MD slope of Humphry's 10-2 program. The results obtained revealed that there was no co-relationship between ARMS2 polymorphisms and MD slopes. These results suggest that the ARMS2 polymorphism (Ala69Ser) may not play as a modifier of the central visual field constriction in patients with retinitis pigmentosa.