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The identification and prevention of the mechanism of photoreceptor cell death

The identification and prevention of the mechanism of photoreceptor cell death
感光细胞死亡机制的识别和预防
批准号:
21592229
负责人:
TSUJIKAWA Motokazu
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
We revealed that zebrafish photoreceptor cell death model ovl shows photoreceptor cell death which relates phototransduction cascade. The cell death mechanism connects at transducine with phototransduction via adenylyl cyclase. Then we established RP zebrafish model which possesses human Q344X mutated rhodoposin. The mechanism of photoreceptor cell death was observed in this model and other mammalian RP model and will be a novel target of RP theraphy.
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Intravitreal bevacizumab for exudative branching vascular networks in polypoidal choroidal vasculopathy
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DOI: 10.1136/bjo.2011.204123
发表时间: 2012
期刊: Br J Ophthalmol
影响因子: --
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DOI: --
发表时间: 2009
期刊:
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作者: [Fukuoka H, et al, 辻川元一]
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Phase I traial of Anti-VEGFR Vaccine Therapy for Neovascular Maculopathy
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DOI: --
发表时间: 2011
期刊:
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作者: [田邊裕貴, 伊藤逸毅, 寺崎浩子, Inoue R, Tsujikawa M]
通讯作者: Tsujikawa M
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    The mechanism of photoreceptor cell death in zebrafish disease models
    • 批准号:
      18689042
    • 项目类别:
      Grant-in-Aid for Young Scientists (A)
    • 资助金额:
      $17.72万
    • 财政年份:
      2006
    • 负责人:
      TSUJIKAWA Motokazu
    • 依托单位:
    海外基金