Pathogenesis of age-related macular degeneration. involvement of lipid peroxidation by photic stress and innate immunity

这项研究的长期目标是揭示年龄相关性黄斑变性(AMD)的发病机制，并开发根治性治疗方法。我们成功地建立了一种新的AMD动物模型，该模型类似于人类AMD，通过低剂量照射成功。长期(^~6个月)强蓝光照射。我们证明了这种光应激和慢性炎症参与了脂质过氧化。我们还研究了先天免疫参与AMD的发生发展，发现低剂量的细菌壁主要成分脂多糖预处理抑制了脉络膜新生血管的发展，并揭示了IL-10在这种免疫修饰机制中的重要作用。

The long term aim of this research is to reveal the pathogenesis of age-related macular degeneration(AMD) and develop a radical treatment. We successfully developed a new animal model of AMD which is similar to human AMD, by irradiating a low. intensity blue light for a long term(^~ 6 months). We demonstrated an involvement of lipid peroxidation by this photic stress and a chronic inflammation. We also investigated an involvement of innate immunity to the development of AMD, and found that a pretreatment with low dose lipopolysaccharide, the major component of the bacteria wall suppressed the development of choroidal neovascularization, and revealed that IL-10 plays an important role in the mechanism of this immune modification.