Functional analysis of mu-crystallin in intra ocular inflammation

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Three types of murin intraocular inflammation model ; endotoxin-induced uveitis, experimental autoimmune uveoretinitis, and laser-induced choroidal neovascularization was established. The inflammation was mildly reduced in CRYM knock-out mice in all models. The CRYM may be associated with macrophages at second peak rather than neutrophils at first peak in anterior chamber of the eyes with EIU.