Effect of infliximab on gene expression profiling in Behcet's disease using microarray analysis

在这项研究中，我们研究了英夫利西单抗对白塞病患者（4例）外周血单个核细胞基因表达模式的影响，在开始英夫利西单抗治疗之前和之后。基因芯片分析显示，所有患者中有8个基因表达下调，1个基因表达上调。定量PCR分析表明，CLEC4E，ets2和TLR2的基因表达在所有患者中下调。因此，在这项研究中发现的几个上调或下调的基因可能是进一步研究的候选人，在描绘的分子机制英夫利昔单抗治疗白塞氏病难治性葡萄膜视网膜炎。

In this study, we investigated the effect of infliximab on gene expression patterns in peripheral blood mononuclear cells of Behcet's disease patients(4 cases) before and after initiation of infliximab treatment. Microarray analysis showed that 8 genes were down-regulated and 1 gene was up-regulated in all patients. Quantitative PCR analysis demonstrated that gene expression of CLEC4E, ets2, and TLR2 was down-regulated in all patients. Thus, several up-regulated or down-regulated genes identified in this study may be candidates for further studies in delineating the molecular mechanism of infliximab for the treatment of Behcet's disease with refractory uveoretinitis.