Analysis for genetic alteration of oral precancerous lesions

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In this study, we successfully established field-cancerization animal model of tongue carcinoma. The model provides well compatibility of macroscopic and microscopic findings and analysis for chronological and site specific changes of the precancerous lesion. In this model, the precancerous lesion shows diffuse epithelial dysplasia and the grade of histological atypia was increased during the carcinogen administration period, although interruption of the administration of the carcinogen brought decrease the atypia but further advanced lesions such as focal protrude lesion and invasive carcinoma.There is high level expression of genes related with double strands DNA damage repair in the precancerous lesions, and it suggests that different properties from in the invasive carcinoma.