Effect of nitric oxide on mechanism of hematogenous metastasis and analysis of prevention of metastasis in adenoid cystic carcinoma

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To elucidate effect of nitric oxide on mechanism of hematogenous metastasis and analysis of prevention of metastasis in adenoid cystic carcinoma, efficacy of single agent or combination chemotherapy of NOS inhibitor and CXCR4 antagonist was examined using xenograft mouse models of human adenoid cystic carcinoma. Treatment with iNOS inhibitor and combined therapy induced apoptosis and significant inhibitory effect for tumor-induced angiogenesis and proliferation of ACCIM. Blocking CXCR4 and iNOS inhibited lung metastasis of adenoid cystic carcinoma, suggesting that CXCR4 and iNOS may become molecular targets to inhibit tumor progression.