The application of Ca^<2+> channel blockers having analgesic properties to general anesthesia-in order not to depend on narcotics in anesthesia-

术前服用钙离子通道阻滞剂对麻醉效果的影响分析九州大学附属医院口腔麻醉科10年来的麻醉病例。我们的研究表明，术前服用l型Ca2+通道阻滞剂可能不会显著影响全麻的作用。本研究没有检查n型Ca2+通道阻滞剂对全身麻醉和静脉镇静的影响，因为很少有患者使用这种类型的药物。麻醉药和Ca2+通道阻滞剂对神经递质释放的影响几乎所有的兴奋性突触前钮扣都附着在树突棘上，而抑制性钮扣大部分位于胞体或树突基部。异丙酚和戊巴比妥抑制了高钾离子诱导的树突钮扣突触前钙离子浓度（[Ca2+] pre）的升高，但对胞体和树突基部钮扣的[Ca2+]含量没有影响。异丙酚抑制谷氨酸诱导的树突钮扣中[Ca2+] pre的增加。异丙酚和戊巴比妥可能通过抑制[Ca2+] pre的增加而影响兴奋性突触前神经终端的神经递质释放

Effects of preoperative taking Ca2+ channel blockers on anesthesiaWe analyzed the anesthesia cases during a ten-year period in the department of dental anesthesiology, Kyushu university hospital. Our studies suggest that preoperative taking L-type Ca2+ channel blockers may not significantly affect the action of general anesthetics. This study did not examine the effects of N-type Ca2+ channel blockers on general anesthesia and intravenous sedation, because there were few patients who took such type of agents.Effects of anesthetics and Ca2+ channel blockers on neurotransmitter release Almost all excitatory presynaptic boutons attach to dendritic spines, and the inhibitory boutons are largely located on the soma or at the base of the dendrite. Propofol and pentobarbital suppressed the high K+ induced increase in presynaptic calcium concentration([ Ca2+] pre) in the boutons attached to the dendrite, they did not affect[ Ca2+ piee in the boutons attached to the soma or dendrite base. Propofol inhibited glutamateinduced increase in[ Ca2+] pre in the boutons attached to the dendrite. Propofol and pentobarbital may affect neurotransmitter release from the excitatory presynaptic nerve terminals due to inhibition of increase in[ Ca2+] pre