A study of inhibitory effect by apoptosis inhibitors on root resorption

为了评价细胞凋亡抑制剂对正畸诱导的牙根吸收的影响，将一种正畸矫治器应用于大鼠。用几种细胞凋亡抑制剂氯化锂和司来吉兰对大鼠牙根进行治疗，观察牙根吸收情况。未观察到任何一种细胞凋亡抑制剂对牙根吸收的抑制作用。然而，在本研究过程中，发现去卵泡大鼠的牙根吸收增加，而氟处理的大鼠的牙根吸收则受到抑制。

In order to evaluate the effect of apoptosis inhibitors on orthodontically induced root resorption, an orthodontic appliance was applied on the rats. Several apoptosis inhibitors such as lithiun cloride and selegiline hydrocloride were administrated to the rats and the root resorption was measured. The inhibitory effect of any apoptosis inhibitor on root resorption was not observed. However, in the course of this study, root resorption in the ovalectomized rats was found to be increased, on the other hand, root resorption of the fluoride-treated rats was found to be inhibited.