Identification of novel nerve injury-induced proteins and their roles in ion channel modulation and pain transduction

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We explored genes whose protein products were assumed to be released into the extracellular space after axotomy of rat sciatic nerve, and identified glycoprotein non-metastatic melanoma B(Gpnmb) as a candidate. Gpnmb expression was detected in infiltrating macrophages in the nerve ends. Also, Gpnmb was expressed in microglia in the layers I and II of the spinal dorsal horn of normal rats. These results suggest that Gpnmb might be involved in the modulation of pain transduction.