Development of Inhibitors for Serine-Threonine Protein Phosphatase

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We were interested in development of specific inhibitors for PP1 and PP2A, which would be expected to contribute to mechanistic elucidation of a cellular signal transduction as a final goal. For the purpose, we tried to search for specific substrates for the enzymes, PP1 and PP2A, as a first step. We expected that the specific substrate could be transformed into a specific inhibitor by a partial structural transformation. As a result, we succeeded to find the specific substrate for PP1.