Elucidation of the healing mechanism for developing gene therapy in palatal wounds

腭裂患者在婴儿期手术修复腭裂缺损后，上颌生长发育障碍，牙弓狭窄。这被认为是腭面伤口愈合过程中形成的疤痕的结果。Smad3是TGF-b信号通路的相关成员之一，其缺失的小鼠在损伤的上颚表现出明显的加速伤口愈合。在这项研究中，我们研究了Smad3磷酸化特异性抑制剂在伤口修复中的作用，结果发现炎症基因下调，伤口愈合加速。

Cleft palate patients are often subject to maxillary growth impairment and narrow dental arch after surgical closure of the defect in infancy. This is considered to be a consequence of the scar which is formed during palatal wound healing. Smad3 is one of the members concerned to TGF-b signaling pathway, and its deficient mice showed the notably accelerated wound healing in injured palates.In this study, we investigated the effects of a specific inhibitor of Smad3 phosphorylation in wound repair, and as a result, an accelerated wound closure with down regulation of inflammatory genes was observed.