Elucidation of the healing mechanism for developing gene therapy in palatal wounds

阐明腭部伤口基因治疗的愈合机制

• 批准号: 21792078
• 负责人: YASUE Akihiro
• 金额: $ 2.83万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792078/
• 关键词: 遺伝子医薬開発; RNAi; Smad3; 療痕形成抑制; SIS3; 瘢痕形成抑制

Cleft palate patients are often subject to maxillary growth impairment and narrow dental arch after surgical closure of the defect in infancy. This is considered to be a consequence of the scar which is formed during palatal wound healing. Smad3 is one of the members concerned to TGF-b signaling pathway, and its deficient mice showed the notably accelerated wound healing in injured palates.In this study, we investigated the effects of a specific inhibitor of Smad3 phosphorylation in wound repair, and as a result, an accelerated wound closure with down regulation of inflammatory genes was observed.

腭裂患者在婴儿期手术闭合缺损后常常会出现上颌骨生长障碍和牙弓狭窄。这被认为是腭伤口愈合过程中形成疤痕的结果。 Smad3 是 TGF-b 信号通路的成员之一，其缺陷小鼠的上腭损伤的伤口愈合明显加快。在本研究中，我们研究了 Smad3 磷酸化的特异性抑制剂在伤口修复中的作用，结果观察到伤口愈合加速，炎症基因下调。

项目成果

Periostin Negatively Regulates Osteoblastic Differentiation in Human Periodontal Ligament Cells

Periostin 负调节人牙周膜细胞的成骨细胞分化

• 发表时间: 2009
• 作者: 渡邉哲平;泰江章博;藤原慎視;田中栄二
• 通讯作者: 田中栄二

Smad3遺伝子機能抑制が瘢痕組織形成に及ぼす影響

Smad3基因功能抑制对疤痕组织形成的影响

• 发表时间: 2010
• 作者: 泰江章博;米田尚子;渡邉哲平;田中栄二;泰江章博;泰江章博
• 通讯作者: 泰江章博

Application of SIS3, a prospective drug, for wound repair accelration

前瞻性药物SIS3在伤口加速修复中的应用

• 发表时间: 2011
• 作者: 泰江章博

Effects of the inhibition of Smad3 phosphorylation on wound healing

抑制Smad3磷酸化对伤口愈合的影响

• 发表时间: 2010
• 作者: Yasue A;et al.
• 通讯作者: et al.