Mechanism, prevention, and treatment of the nitrogen-containing bisphosphonate-related osteonecrosis of the jaw.

含氮双膦酸盐（NBPs）是一种有效的抗骨吸收药物，但也会引起意想不到的新副作用，即颌骨骨坏死（ONJ）。在接受非nbps治疗的患者中很少有ONJ病例的报道。单次皮下注射NBP到耳廓可诱导注射部位的组织IL-1b和IL-18，而非NBP则没有这种作用。LPS增强NBP诱导的炎症细胞因子，非NBP与NBP联合使用可消除这种增强作用。

Nitrogen-containing bisphosphonates (NBPs) are powerful anti-bone-resorptive drugs, but they induce unexpected new side effect, osteonecrosis of the jaw (ONJ). Few ONJ cases have been reported in patients treated with non-NBPs. A single subcutaneous injection of an NBP into the ear pinna induced tissue IL-1b and IL-18 at the injection site, while non-NBP lacked this effect. LPS augments the NBP-induced inflammatory cytokines, co-administration of non-NBP with NBP abolishes these augmentations.