P.gingivalis target DC-SIGN to escape Th1-type immune response.

牙龈卟啉单胞菌以 DC-SIGN 为靶点来逃避 Th1 型免疫反应。

• 批准号: 21792108
• 负责人: TADA Hiroyuki
• 金额: $ 2.66万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792108/
• 关键词: 免疫学; 樹状細胞; 細胞・組織; サイトカイン; DC-SIGN

Dendritic cells (DCs) express C-type lectin receptors (CLRs). Pathogenic bacteria subvert DC functions to escape immune surveillance by targeting the CLRs including DC-SIGN. In this study, we investigated the role played by Nod proteins in inducing the cross-priming of CD8^+T cells, and we demonstrate that Nod ligands significantly enhance the induction of DC-mediated cross-priming.

树突状细胞（DC）表达C型凝集素受体（CLRs）。病原菌通过靶向包括DC-SIGN在内的CLR破坏DC功能以逃避免疫监视。在这项研究中，我们研究了Nod蛋白在诱导CD 8 ^+T细胞交叉致敏中所起的作用，我们证明了Nod配体显著增强了DC介导的交叉致敏的诱导。

项目成果

Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells

• DOI: 10.1016/j.bbrc.2010.03.135
• 发表时间: 2010-04-16
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Tada, Hiroyuki;Nemoto, Eiji;Shimauchi, Hidetoshi
• 通讯作者: Shimauchi, Hidetoshi

Phosphate increases bone morphogenetic protein-2 expression through cAMP-dependent protein kinase and ERK1/2 pathways in human dental pulp cells

• DOI: 10.1016/j.bone.2011.03.675
• 发表时间: 2011-06-01
• 期刊: BONE
• 影响因子: 4.1
• 作者: Tada, Hiroyuki;Nemoto, Eiji;Shimauchi, Hidetoshi
• 通讯作者: Shimauchi, Hidetoshi

Nucleotide-binding oligomerization domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo.

核苷酸结合寡聚化结构域样受体信号传导增强树突状细胞介导的体内交叉引发。

• 发表时间: 2010
• 期刊: J.Immunol. 184
• 作者: Asano;J.;Tada;H.;Onai;N.;Sato;T.;Horie;Y.;Fujimoto;Y.;Fukase;K.;Suzuki;A.;Mak;T.W.;Ohteki;T.
• 通讯作者: T.

Nucleotide-binding oligomerization domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo

核苷酸结合寡聚化结构域样受体信号传导增强树突状细胞介导的体内交叉引发

• 发表时间: 2010
• 期刊: J.Immunol. 184
• 作者: Asano;J.
• 通讯作者: J.

Transitions in Oral and Intestinal Microflora Composition and Innate Immune Receptor-Dependent Stimulation during Mouse Development

• DOI: 10.1128/iai.01043-09
• 发表时间: 2010-02-01
• 期刊: INFECTION AND IMMUNITY
• 影响因子: 3.1
• 作者: Hasegawa, Mizuho;Osaka, Toshifumi;Inohara, Naohiro
• 通讯作者: Inohara, Naohiro