Analysis of novel periodontal ligament-specific molecules identified in human periodontal ligament full-length cDNA database.

分析人牙周膜全长 cDNA 数据库中鉴定的新型牙周膜特异性分子。

• 批准号: 21792119
• 负责人: OZAWA Yasuhiro
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792119/
• 关键词: 歯根膜組織完全長cDNAライブラリ; ヒト歯根膜組織完全長cDNAデータベース; 新規遺伝子; 歯根膜組織; FLJ25143遺伝子; Cathepsin K

In this study, I analyzed human periodontal ligament full-length cDNA library ( Full-PerioGen database ) and found several genes which were highly expressed in human periodontal ligament tissues. Among of these genes, I focused on FLJ25143 and Cathepsin K of which functions in periodontal ligament were not known. I found that FLJ25143 and Cathepsin K regulated periodontal ligament cell functions, suggesting involvement of these molecules in homeostasis, repair and regeneration of periodontium.

在本研究中，我分析了人牙周膜全长cDNA文库（Full-PerioGen数据库），发现了几个在人牙周膜组织中高表达的基因。其中，FLJ 25143和Cathepsin K在牙周膜中的功能尚不清楚。我发现FLJ 25143和组织蛋白酶K调节牙周膜细胞的功能，表明这些分子参与牙周组织的稳态，修复和再生。