Analysis of novel periodontal ligament-specific molecules identified in human periodontal ligament full-length cDNA database.

在这项研究中，我分析了人牙周膜全长cDNA文库(Full-PerioGen数据库)，发现了几个在人牙周膜组织中高表达的基因。在这些基因中，我重点研究了在牙周膜中功能未知的FLJ25143和组织蛋白酶K。我发现FLJ25143和组织蛋白酶K调节牙周韧带细胞的功能，提示这些分子参与了牙周组织的动态平衡、修复和再生。

In this study, I analyzed human periodontal ligament full-length cDNA library ( Full-PerioGen database ) and found several genes which were highly expressed in human periodontal ligament tissues. Among of these genes, I focused on FLJ25143 and Cathepsin K of which functions in periodontal ligament were not known. I found that FLJ25143 and Cathepsin K regulated periodontal ligament cell functions, suggesting involvement of these molecules in homeostasis, repair and regeneration of periodontium.