Development of a sensing system for thrombus formation factors produced by periodontopathic bacterium.

为了研究牙周炎与心肌梗死之间的关系，我们开发了一种牙周病细菌产生血栓形成因子的传感系统。结果，我们观察到巨噬细胞在LPS存在下斑块形成增加。此外，感染放线菌聚集菌后，斑块形成减少。结果表明，LDL刺激可显著增强巨噬细胞泡沫细胞的形成。

To investigate the relation between periodontitis and myocardial infarction, we have developed a sensing system for thrombus formation factors produced by periodontopathic bacterium. As a result, we observed increased plaque formation by macrophages in the presence of LPS. In addition, the plaque formation was decreased after infection with Aggregatibacter actinomycetemcomitans. We showed that foam cell formation in macrophages was significantly enhanced by stimulation of LDL.