視覚情報処理過程における視床抑制性神経核の機能的役割

丘脑抑制核在视觉信息处理过程中的功能作用

• 批准号: 09J04665
• 负责人: 尾崎 弘展
• 金额: $ 1.34万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09J04665/
• 关键词: 外側膝状体; 視床網様核; 神経回路; 視覚系; 抑制性入力

網膜から入った視覚情報は視床外側膝状体(Lateral geniculate nucleus:LGN)において様々な処理を受けた後に、大脳皮質一次視覚野へと伝達される。LGNでの情報処理過程において重要な働きを担っているのがLGNの中継細胞への抑制性入力である。この抑制性入力は、LGN内の介在細胞と抑制性神経核である視床網様核から与えられる。ネコなどの食肉目では視床網様核の一部である膝状体周囲核(perigeniculate nucleus:PGN)が抑制性入力の主たる入力源として働く。一般にLGNとPGNは相互に結合しており、LGNから興奮性入力を受けたPGNが抑制性入力をLGNへと返す、反回性抑制回路を形成している。しかしながら、単一細胞レベルでLGNとPGNがどのように結合しているのかは明らかにされていなかった。本研究では、LGN、PGN、それぞれの細胞の視覚特徴選択性と結合の関係を調べ、同じ位置に受容野をもち機能的結合関係にあるLGNとPGNであっても、それぞれの視覚特徴選択性の観点から見ると、側方抑制として働いていることを明らかにし、本年度、国際学会等でその成果を発表した。

The retina enters the visual field and the lateral geniculate nucleus (LGN) enters the visual field. The information processing of LGN is very important, and the inhibitory force of LGN is very important. The inhibitory forces are mediated in the cells of the LGN, and the inhibitory neurons are mediated in the optic bed network. A part of the perigeniculate nucleus (PGN) is the main source of inhibitory force. In general, LGN and PGN combine with each other, and LGN and PGN inhibit each other. It's like a single cell, but LGN and PGN are like a single cell, and they are combined. In this study, the relationship between LGN, PGN and PGN in the selection of visual characteristics and the combination of functions in the same position, the relationship between LGN and PGN in the selection of visual characteristics and the combination of functions in the same position, the relationship between LGN and PGN in the selection of visual characteristics and the relationship between LGN and PGN in the selection of visual characteristics, the relationship between LGN and PGN in the selection of visual characteristics and the relationship between LGN and PGN in the selection of visual characteristics, the relationship between LGN and PGN in the selection of visual characteristics and the relationship between LGN and PGN in the selection of visual characteristics, the relationship between LGN and PGN in the selection of visual characteristics, the relationship between LGN and PGN in the selection of visual characteristics, the relationship between LGN and PGN in the selection of visual characteristics, the relationship between LGN and PGN in the selection of visual characteristics and the selection of visual characteristics, the relationship between LGN and PGN in the selection of visual characteristics, and the relationship between LGN and PGN in the same position, the relationship between LGN and PGN in the

项目成果

Surround suppression by high spatial frequency stimuli in the cat primary visual cortex

• DOI: 10.1111/j.1460-9568.2010.07572.x
• 发表时间: 2011-01
• 期刊: European Journal of Neuroscience
• 影响因子: 3.4
• 作者: Hironobu Osaki;T. Naito;O. Sadakane;M. Okamoto;Hiromichi Sato

ネコ外側膝状体と視床網様核の活動相互相関法の解析

猫外侧膝状体与丘脑网状核活动互相关法分析

• 发表时间: 2010
• 作者: Masaya Ito;Leslie Greenberg;伊藤正哉・樫村正美・堀越勝;尾崎弘展
• 通讯作者: 尾崎弘展

The role of surround suppression at high spatial frequency in the cat V1 : A possible basis for scale-invariant processing

cat V1 中高空间频率的环绕声抑制的作用：尺度不变处理的可能基础

• 发表时间: 2009
• 作者: Masaya Ito;Leslie Greenberg;伊藤正哉・樫村正美・堀越勝;尾崎弘展;Hironobu Osaki
• 通讯作者: Hironobu Osaki