Development of X-ray sensitizing therapy by precisely designed polymers bearing heavy metals

本计画开发X线增感材料，以降低放射线剂量，应用于癌症放射治疗。采用活性自由基聚合法制备了核内含有多种金属的含金属星星聚合物，并将其用作X射线增感剂。将获得的含金属的星星聚合物加入HeLa细胞中并孵育。然后用X射线照射细胞。含有星星聚合物的细胞比不含星星聚合物的细胞被杀死，这表明含金属的星星聚合物实际上起X射线敏化剂的作用。

In this project, X-ray sensitizing material was developed for radiation therapy of cancer to reduce irradiation dose. Metal-bearing star polymer, which has many metals in its core, was prepared by living radical polymerization and was employed as an X-ray sensitizer. The obtained metal-bearing star polymer was added to HeLa cells and incubated. X-ray was then irradiated to the cells. More cells containing the star polymer were killed than that without the star polymer, which indicates that the metal-containing star polymer actually worked as an X-ray sensitizer.