Development of X-ray sensitizing therapy by precisely designed polymers bearing heavy metals

在本项目中，开发了用于癌症放射治疗的X射线增敏材料，以降低辐射剂量。采用活性自由基聚合法合成了核中含有多种金属的含金属星形聚合物，并将其用作X射线增敏剂。将得到的含金属星形聚合物加入HeLa细胞中孵育。然后将X射线照射到细胞上。含有星形聚合物的细胞比没有星形聚合物的细胞被杀死的细胞更多，这表明含有金属的星形聚合物实际上起到了X射线增敏剂的作用。

In this project, X-ray sensitizing material was developed for radiation therapy of cancer to reduce irradiation dose. Metal-bearing star polymer, which has many metals in its core, was prepared by living radical polymerization and was employed as an X-ray sensitizer. The obtained metal-bearing star polymer was added to HeLa cells and incubated. X-ray was then irradiated to the cells. More cells containing the star polymer were killed than that without the star polymer, which indicates that the metal-containing star polymer actually worked as an X-ray sensitizer.