Development of X-ray sensitizing therapy by precisely designed polymers bearing heavy metals

通过精确设计的含重金属聚合物开发 X 射线增敏疗法

• 批准号: 21300164
• 负责人: ANDO Tsuyoshi
• 金额: $ 5.57万
• 依托单位: Nara Institute of Science and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300164/
• 关键词: ナノバイオロジー; ナノメディスン; X線増感; スターポリマー; 高分子薬剤; がん治療; 金属含有高分子; 星型高分子; リビングラジカル重合

In this project, X-ray sensitizing material was developed for radiation therapy of cancer to reduce irradiation dose. Metal-bearing star polymer, which has many metals in its core, was prepared by living radical polymerization and was employed as an X-ray sensitizer. The obtained metal-bearing star polymer was added to HeLa cells and incubated. X-ray was then irradiated to the cells. More cells containing the star polymer were killed than that without the star polymer, which indicates that the metal-containing star polymer actually worked as an X-ray sensitizer.

本计画开发X线增感材料，以降低放射线剂量，应用于癌症放射治疗。采用活性自由基聚合法制备了核内含有多种金属的含金属星星聚合物，并将其用作X射线增感剂。将获得的含金属的星星聚合物加入HeLa细胞中并孵育。然后用X射线照射细胞。含有星星聚合物的细胞比没有星星聚合物的细胞被杀死的更多，这表明含有金属的星星聚合物实际上起到了X射线增敏剂的作用。

项目成果

Eu-bearing Star Polymers : Syntheses by Living Radical Polymerization and Their Photoproperties

含铕星形聚合物:活性自由基聚合合成及其光性能

• 发表时间: 2012
• 作者: Ahmad Kusumaatmaja;Kayo Terada;Shiho Hirohara;Tsuyoshi Ando;Masao Tanihara
• 通讯作者: Masao Tanihara