Central mechanisms underlying antihypertensive effects of daily exercise in hypertension

每日锻炼与降压相关；然而，其机制尚不清楚。为了探讨这一点，我们研究了日常运动对自发性高血压大鼠（SHR）调节血压的重要脑区——孤立束核（NTS）的影响。我们已经发现，日常运动改变了SHR NTS中的基因表达谱和神经元功能。这些结果提示NTS的可塑性改变可能与日常运动的降压作用有关。此外，我们还得出结论，血清素系统可能在日常运动引起的NTS功能变化中起重要作用。

Daily exercise has been associated with antihypertensive benefits ; however, its mechanisms remain unclear. To explore this, we have investigated the effects of daily exercise on an important brain area in regulating blood pressure, the nucleus of the solitary tract(NTS), in spontaneously hypertensive rats(SHR). We have revealed that daily exercise alters gene expression profiles and neuronal functions in the NTS of SHR. These results suggest that the plastic changes in the NTS may be involved in the antihypertensive effects of daily exercise. Moreover, we have concluded that the serotoninergic system may have an important role in the functional changes in the NTS induced by daily exercise.