Control of a small amount of molecules in two-dimensional monolayer by local modification

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We revealed that molecules with distinct sizes and strictures in self-spreading lipid bilayer are selectively filtered when the bilayer spread through the metallic nanogates. In order to make clear the origin of this molecular filtering phenomenon, we have observed molecular diffusion in nano space by single molecular tracking. In this research, metal nanogates with sizes of 100 nm was fabricated on cover slips with using electron beam lithography. The quantitative evaluation by single molecular tracking can reveal that the structural change of lipid bilayer correlates molecular diffusion change in nano space.