Capture of diatomic molecules by supramolecular heme protein models and application to development to medicinal chemistry

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HemoCD, which is composed of a water-soluble iron porphyrin(FeTPPS) and a per-methylated β-cyclodextrin dimer(Py3CD), was attached to poly(acrylic acid) s or gold nano-particles to inhibit glomerular filtration of hemoCD. These modified hemoCDs, which were regarded as the hemoglobin(Hb) and myoglobin(Mb) models, were not excluded in the urine of a rat, suggesting that the modified hemoCDs stay in the blood for a long time. We also tried to apply the present supramolecular system to medicinal chemistry. At first, the removal of endogenous carbon monoxide of a rat was examined by infusing hemoCD solution into the femoral vein. Injected hemoCD was rapidly excreted in the urine in the form of a carbon monoxide adduct, indicating that hemoCD can be used as an antidote of CO poisoning. Meanwhile, hemoCD was unfavorable for the cyanide poisoning. Then we prepared a supramolecule, Im3CD/Fe(III) TPPS complex, which strongly captured the cyanide anion in a rat's body. Since this cyanide remover did not interact with bovine proteins, the Im3CD/Fe(III) TPPS complex was assumed to be better antidote than hydroxocobalamin.